Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands

Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands.

Chemically functionalized and nanostructured materials, which mimic the features of the natural extracellular matrix, provide a tool to organize cell surface receptors into nanoscale clusters and manipulate cell functions. However, the existing materials are mainly based on static structures. Herein, we developed a DNA based structure-switchable and multivalent material that acts as a 'nano-spr...

Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands† †Electronic supplementary information (ESI) available: Sequence information and synthesis of the RGD–DNA conjugate. See DOI: 10.1039/c7sc02489d Click here for additional data file.

Binding of Multivalent Ligands to Cells: E ects of Cell and Receptor Density Condensed title: Binding of Multivalent Ligands (Keywords: Multivalent Ligands, Crosslinking

We study the equilibrium binding properties of multivalent ligands and mixtures of ligands of diierent valence to cell surface receptors. We examine the eeects of changing cell density or number of receptors per cell, i.e., receptor concentration, over a wide but physiologically relevant range. Qualitatively diierent behaviour arises in the excess receptor regime, where the volume concentration...

synthesis of amido alkylnaphthols using nano-magnetic particles and surfactants

we used dbsa and nano-magnetic for the synthesis of amido alkylnaphtols.

Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions.

BACKGROUND Ring-opening metathesis polymerization (ROMP) is a powerful synthetic method for generating unique materials. The functional group tolerance of ruthenium ROMP initiators allows the synthesis of a wide range of biologically active polymers. We generated multivalent ligands that inhibit cell surface L-selectin, a protein that mediates lymphocyte homing and leukocyte recruitment in infl...